N-Alkylation of Anthracycline Antibiotics by Natural Sesquiterpene Lactones as a Way to Obtain Antitumor Agents with Reduced Side Effects

N-Alkylation of Anthracycline Antibiotics by Natural Sesquiterpene Lactones as a Way to Obtain Antitumor Agents with Reduced Side Effects

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Anthracycline antitumor antibiotics are one of the promising classes of chemotherapeutic agents for cancer treatment.The main deterrent to their use is high toxicity to a healthy environment, including cumulative cardiotoxicity.In our work, bipharmacophore molecules containing in their structure a fragment of the known anthracycline antibiotics daunorubicin and doxorubicin and natural “This is fine”: the impact of blowouts on subsequent game performance in the National Hockey League (NHL) sesquiterpene lactones were obtained for the first time.When studying the biological activity of the synthesized compounds, it was found that with equal and, in some cases, higher cytotoxicity and glycolysis inhibition by anthracycline antibiotics conjugates with sesquiterpene lactones in comparison with doxo- and daunorubicin, a reduced damaging effect on the functioning of rat heart mitochondria was observed.The results obtained allow us to confirm the assumption that the chemical modification of the anthracycline antibiotics molecules doxo- and daunorubicin by natural sesquiterpene lactones can be a promising strategy for creating potential antitumor chemotherapeutic drugs with a pronounced cytotoxic effect on tumor cells and A Dynamic and Adaptive Selection Radar Tracking Method Based on Information Entropy a reduced damaging effect on healthy cells of the human organism.